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KMID : 0370220200640040307
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Yakhak Hoeji
2020 Volume.64 No. 4 p.307 ~ p.311
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Effect of Eleutheroside E from Eleutherococcus senticosus on the Contractility of Rabbit Penile Corpus Cavernosum Smooth Muscle
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Kim Min-Ji
Choi Yun-Sik
Jang Young-Ah
Kim Hye-Kyung
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Abstract
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The relaxant effect of extract, fractions and major component, eleutheroside E, from Eleutherococcus senticosuswas evaluated on penile corpus cavernosum smooth muscle (PCCSM) in a rabbit. The PCCSM contracted with 10 μMphenylephrine (Phe) was treated with extract and three fractions partitioned with n-hexane, ethyl acetate and n-butanol ata range of 1?4 mg/ml. Eleutheroside E was tested at final concentrations of 0.1, 1, 10 and 100 μM. The interaction ofeleutheroside E with phosphodiesterase type 5 (PDE5) inhibitor, udenafil, was also evaluated on PCCSM tension. Therelaxations induced by ethanol extract and three fractions on PCCSM were effective in a dose-dependent manner and therelaxation of ethyl acetate fraction was the highest. Eleutheroside E dose-dependently induced the PCCSM relaxation andshowed an additive effect with udenafil on PCCSM. The extract, ethyl acetate fraction and eleutheroside E from E. senticosus relaxed the Phe-precontracted PCCSM and eleutheroside E enhanced the udenafil-induced relaxation. It can bean alternative or supplement for patients with erectile dysfunction who want herbal medicines to improve penile erectionor who do not completely respond to udenafil.
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KEYWORD
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Eleutherococcus senticosus, eleutheroside E, penile corpus cavernosum smooth muscle, phosphodiesterase type 5 inhibitor
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